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Proliferation of bony metastasis ofprostate/breast cancer and multiple myeloma cellsmay be arrested.

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[ 43] provided a detailed kinetic characterizationof this interaction.

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Nutlins wereone class of lead structures identied and optimized for potency and selectivity.These compounds displaced the recombinant p53 protein from its complex withMDM2 at inhibitory concentration (IC50) values in the 100–300 nM range.Nutlin-1 and Nutlin-2 are racemic mixtures, and Nutlin-3a is an active enantiomerisolated from racemic Nutlin-3. Given the practical and fi nancial limitationsof interventional studies, very few foods and nutrients(mostly vitamin supplementations) have been evaluatedin large multicenter, randomized clinical trials in olderpersons

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